Selected publications

Full publication list at NCBI.

 

Since 2016

 

  • Han T*, Jiang S*, Zheng H, Yin Q, Xie M, Little MR, Yin X, Chen M, Song SJ, Beg AA, Pandolfi PP, Wan L. Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis. Nature Communications. 2019 Aug 16;10(1):3716. PubMed PMID: 31420536; PubMed Central PMCID: PMC6697746. doi: 10.1038/s41467-019-11618-7.

  • Yin Q, Han T, Fang B, Zhang G, Zhang C, Roberts ER, Izumi V, Zheng M, Jiang S, Yin X, Kim M, Cai J, Haura EB, Koomen JM, Smalley KSM, Wan L. K27-linked ubiquitination of BRAF by ITCH engages cytokine response to maintain MEK-ERK signaling. Nature Communications. 2019 Apr 23;10(1):1870. PubMed PMID: 31015455; PubMed Central PMCID: PMC6478693. doi: 10.1038/s41467-019-09844-0.

  • Wan L*, Xu K*, Wei Y*, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Liu J, Wu Y, Jin VX, Dai X, Guo J, Liu J, Jiang S, Li J, Asara JM, Brown M*, Hung MC*, Wei W*. Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. Molecular Cell. 2018 Jan 18;69(2):279-291.e5. PubMed PMID: 29351847; PubMed Central PMCID: PMC5777296. doi: 10.1016/j.molcel.2017.12.024.

  • Wan L*, Chen M*, Cao J*, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R*, Pandolfi PP*, Wei W*. The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function. Cancer Discovery. 2017 Apr;7(4):424-441. PubMed PMID: 28174173; PubMed Central PMCID: PMC5380472. doi: 10.1158/2159-8290.CD-16-0647.

  • Liu J*, Wan L*, Liu J, Yuan Z, Zhang J, Guo J, Malumbres M, Liu J, Zou W, Wei W. Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner. Cell Discovery. 2016;2:15044. PubMed PMID: 27462441; PubMed Central PMCID: PMC4860961. doi: 10.1038/celldisc.2015.44.

  • Shao R*, Liu J*, Yan G, Zhang J, Han Y, Guo J, Xu Z, Yuan Z, Liu J, Malumbres M, Wan L*, Wei W*, Zou W*. Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid. Cell Research. 2016 Jun;26(6):699-712. doi: 10.1038/cr.2016.51. Epub 2016 Apr 29. PubMed PMID: 27126000; PubMed Central PMCID: PMC4897181. doi: 10.1038/cr.2016.51.

 

2011-2015

 

  • Cao J*, Dai X*, Wan L*, Wang H, Zhang J, Goff PS, Sviderskaya EV, Xuan Z, Xu Z, Xu X, Hinds P, Flaherty KT, Faller DV, Goding CR, Wang Y, Wei W, Cui R. The E3 ligase APC/C(Cdh1) promotes ubiquitylation-mediated proteolysis of PAX3 to suppress melanocyte proliferation and melanoma growth. Science Signaling. 2015 Sep 1;8(392):ra87. PubMed PMID: 26329581. doi: 10.1038/celldisc.2015.44.

  • Zhang J*, Wan L*, Dai X, Sun Y, Wei W. Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis. Biochim Biophys Acta. 2014 Apr;1845(2):277-93. 2014 Feb 22. Review. PubMed PMID: 24569229; PubMed Central PMCID: PMC3995847. doi: 10.1016/j.bbcan.2014.02.001.

  • Wan L, Tan M, Yang J, Inuzuka H, Dai X, Wu T, Liu J, Shaik S, Chen G, Deng J, Malumbres M, Letai A, Kirschner MW, Sun Y, Wei W. APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction. Developmental Cell. 2014 May 27;29(4):377-91. PubMed PMID: 24871945; PubMed Central PMCID: PMC4081014. doi: 10.1016/j.devcel.2014.04.022.

  • Cao J*, Wan L*, Hacker E, Dai X, Lenna S, Jimenez-Cervantes C, Wang Y, Leslie NR, Xu GX, Widlund HR, Ryu B, Alani RM, Dutton-Regester K, Goding CR, Hayward NK, Wei W*, Cui R*. MC1R is a potent regulator of PTEN after UV exposure in melanocytes. Molecular Cell. 2013 Aug 22;51(4):409-22. PubMed PMID: 23973372; PubMed Central PMCID: PMC3792490. doi: 10.1016/j.molcel.2013.08.010.

  • Fukushima H*, Ogura K*, Wan L*, Lu Y, Li V, Gao D, Liu P, Lau AW, Wu T, Kirschner MW, Inuzuka H*, Wei W*. SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression. Cell Reports. 2013 Aug 29;4(4):803-16. 2013 Aug 22. PubMed PMID: 23972993; PubMed Central PMCID: PMC3839583. doi: 10.1016/j.celrep.2013.07.031.

  • Wan L*, Zou W*, Gao D, Inuzuka H, Fukushima H, Berg AH, Drapp R, Shaik S, Hu D, Lester C, Eguren M, Malumbres M, Glimcher LH*, Wei W*. Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1. Molecular Cell. 2011;44(5):721-33. Epub 2011/12/14. PubMed PMID: 22152476; PubMed Central PMCID: PMC3240853. doi: 10.1038/s41467-019-09844-0.