Full publications list: https://pubmed.ncbi.nlm.nih.gov/?term=Marusyk+A
2024
Desai, B., Miti, T., Prabhakaran, S., Miroshnychenko, D., Henry, M., Marusyk, V., Gatenbee, C., Bui, M., Scott, J., Altrock, P. M., Haura, E., Anderson, A. R. A., Basanta, D., & Marusyk, A. (2024). Peristromal niches protect lung cancers from targeted therapies through a combined effect of multiple molecular mediators. bioRxiv. https://doi.org/10.1101/2024.04.24.590626
Franca, G. S., Baron, M., King, B. R., Bossowski, J. P., Bjornberg, A., Pour, M., Rao, A., Patel, A. S., Misirlioglu, S., Barkley, D., Tang, K. H., Dolgalev, I., Liberman, D. A., Avital, G., Kuperwaser, F., Chiodin, M., Levine, D. A., Papagiannakopoulos, T., Marusyk, A., . . . Yanai, I. (2024). Cellular adaptation to cancer therapy along a resistance continuum. Nature. https://doi.org/10.1038/s41586-024-07690-9
Marusyk, A. (2024). Evolutionary gambit to defeat drug resistance in cancer. Nat Biotechnol. https://doi.org/10.1038/s41587-024-02284-2
Miti, T., Desai, B., Miroshnychenko, D., Basanta, D., & Marusyk, A. (2024). Dissecting the Spatially Restricted Effects of Microenvironment-Mediated Resistance on Targeted Therapy Responses. Cancers (Basel), 16(13), 2405. https://www.mdpi.com/2072-6694/16/13/2405
2023
Adhikari, E., Liu, Q., Johnson, J., Stewart, P., Marusyk, V., Fang, B., Izumi, V., Bowers, K., Guzman, K. M., Koomen, J. M., Marusyk, A., & Lau, E. K. (2023). Brain metastasis-associated fibroblasts secrete fucosylated PVR/CD155 that induces breast cancer invasion. Cell Rep, 42(12), 113463. https://doi.org/10.1016/j.celrep.2023.113463
Gatenbee, C. D., Baker, A. M., Prabhakaran, S., Swinyard, O., Slebos, R. J. C., Mandal, G., Mulholland, E., Andor, N., Marusyk, A., Leedham, S., Conejo-Garcia, J. R., Chung, C. H., Robertson-Tessi, M., Graham, T. A., & Anderson, A. R. A. (2023). Virtual alignment of pathology image series for multi-gigapixel whole slide images. Nat Commun, 14(1), 4502. https://doi.org/10.1038/s41467-023-40218-9
Miroshnychenko, D., Miti, T., Kumar, P., Miller, A., Laurie, M., Giraldo, N., Bui, M. M., Altrock, P. M., Basanta, D., & Marusyk, A. (2023). Stroma-mediated breast cancer cell proliferation indirectly drives chemoresistance by accelerating tumor recovery between chemotherapy cycles. Cancer Res. https://doi.org/10.1158/0008-5472.CAN-23-0398
2022
Remsing Rix, L. L., Sumi, N. J., Hu, Q., Desai, B., Bryant, A. T., Li, X., Welsh, E. A., Fang, B., Kinose, F., Kuenzi, B. M., Chen, Y. A., Antonia, S. J., Lovly, C. M., Koomen, J. M., Haura, E. B., Marusyk, A., & Rix, U. (2022). IGF-binding proteins secreted by cancer-associated fibroblasts induce context-dependent drug sensitization of lung cancer cells. Sci Signal, 15(747), eabj5879. https://doi.org/10.1126/scisignal.abj5879
Somarelli, J. A., DeGregori, J., Gerlinger, M., Heng, H. H., Marusyk, A., Welch, D. R., & Laukien, F. H. (2022). Questions to guide cancer evolution as a framework for furthering progress in cancer research and sustainable patient outcomes. Med Oncol, 39(9), 137. https://doi.org/10.1007/s12032-022-01721-z
Farrokhian, N., Maltas, J., Dinh, M., Durmaz, A., Ellsworth, P., Hitomi, M., McClure, E., Marusyk, A., Kaznatcheev, A., & Scott, J. G. (2022). Measuring competitive exclusion in non-small cell lung cancer. Sci Adv, 8(26), eabm7212. https://doi.org/10.1126/sciadv.abm7212
Vander Velde, R., Shaffer, S., & Marusyk, A. (2022). Integrating mutational and nonmutational mechanisms of acquired therapy resistance within the Darwinian paradigm. Trends Cancer. https://doi.org/10.1016/j.trecan.2022.02.004
2021
Capp, J. P., DeGregori, J., Nedelcu, A. M., Dujon, A. M., Boutry, J., Pujol, P., Alix-Panabieres, C., Hamede, R., Roche, B., Ujvari, B., Marusyk, A., Gatenby, R., & Thomas, F. (2021). Group phenotypic composition in cancer. Elife, 10. https://doi.org/10.7554/eLife.63518
Miroshnychenko, D., Baratchart, E., Ferrall-Fairbanks, M. C., Velde, R. V., Laurie, M. A., Bui, M. M., Tan, A. C., Altrock, P. M., Basanta, D., & Marusyk, A. (2021). Spontaneous cell fusions as a mechanism of parasexual recombination in tumour cell populations. Nat Ecol Evol, 5(3), 379-391. https://doi.org/10.1038/s41559-020-01367-y
Edwards, J., Marusyk, A., & Basanta, D. (2021). Selection-driven tumor evolution with public goods leads to patterns of clonal expansion consistent with neutral growth. iScience, 24(1), 101901. https://doi.org/10.1016/j.isci.2020.101901
Scott, J., Basanta, D., & Marusyk, A. (2021). Darwinism, Not Mutationalism, for New Cancer Therapies. In B. Strauss, M. Bertolaso, I. Ernberg, & M. J. Bissell (Eds.), Rethinking Cancer: A New Paradigm for the Postgenomics Era. MIT Press. https://mitpress.mit.edu/books/rethinking-cancer
2020
Damaghi, M., Mori, H., Byrne, S., Xu, L., Chen, T., Johnson, J., Gallant, N. D., Marusyk, A., Borowsky, A. D., & Gillies, R. J. (2020). Collagen production and niche engineering: A novel strategy for cancer cells to survive acidosis in DCIS and evolve. Evol Appl, 13(10), 2689-2703. https://doi.org/10.1111/eva.13075
Vander Velde, R., Yoon, N., Marusyk, V., Durmaz, A., Dhawan, A., Miroshnychenko, D., Lozano-Peral, D., Desai, B., Balynska, O., Poleszhuk, J., Kenian, L., Teng, M., Abazeed, M., Mian, O., Tan, A. C., Haura, E., Scott, J., & Marusyk, A. (2020). Resistance to targeted therapies as a multifactorial, gradual adaptation to inhibitor specific selective pressures. Nature Communications, 11(1), 2393. https://doi.org/10.1038/s41467-020-16212-w
Marusyk, A., Janiszewska, M., & Polyak, K. (2020). Intratumor Heterogeneity: The Rosetta Stone of Therapy Resistance. Cancer Cell, 37(4), 471-484. https://doi.org/10.1016/j.ccell.2020.03.007
2016-2019
Kaznatcheev, A., Peacock, J., Basanta, D., Marusyk, A., & Scott, J. G. (2019). Fibroblasts and alectinib switch the evolutionary games played by non-small cell lung cancer. Nat Ecol Evol, 3(3), 450-456. https://doi.org/10.1038/s41559-018-0768-z
Yoon, N., Vander Velde, R., Marusyk, A., & Scott, J. G. (2018). Optimal Therapy Scheduling Based on a Pair of Collaterally Sensitive Drugs. Bull Math Biol. https://doi.org/10.1007/s11538-018-0434-2
Janiszewska, M., Tabassum, D. P., Castano, Z., Cristea, S., Yamamoto, K. N., Kingston, N. L., Murphy, K. C., Shu, S., Harper, N. W., Del Alcazar, C. G., Aleckovic, M., Ekram, M. B., Cohen, O., Kwak, M., Qin, Y., Laszewski, T., Luoma, A., Marusyk, A., Wucherpfennig, K. W., . . . Polyak, K. (2019). Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments. Nat Cell Biol, 21(7), 879-888. https://doi.org/10.1038/s41556-019-0346-x
Taylor-King, J. P., Baratchart, E., Dhawan, A., Coker, E. A., Rye, I. H., Russnes, H., Chapman, S. J., Basanta, D., & Marusyk, A. (2018). Simulated ablation for detection of cells impacting paracrine signalling in histology analysis. Math Med Biol. https://doi.org/10.1093/imammb/dqx022
Scott, J., & Marusyk, A. (2017). Somatic clonal evolution: A selection-centric perspective. Biochim Biophys Acta Rev Cancer, 1867(2), 139-150. https://doi.org/10.1016/j.bbcan.2017.01.006
Marusyk, A., Tabassum, D. P., Janiszewska, M., Place, A. E., Trinh, A., Rozhok, A. I., Pyne, S., Guerriero, J. L., Shu, S., Ekram, M., Ishkin, A., Cahill, D. P., Nikolsky, Y., Chan, T. A., Rimawi, M. F., Hilsenbeck, S., Schiff, R., Osborne, K. C., Letai, A., & Polyak, K. (2016). Spatial Proximity to Fibroblasts Impacts Molecular Features and Therapeutic Sensitivity of Breast Cancer Cells Influencing Clinical Outcomes. Cancer Res, 76(22), 6495-6506. https://doi.org/10.1158/0008-5472.CAN-16-1457
Selected earlier work
Polyak, K., & Marusyk, A. (2014). Cancer: Clonal cooperation. Nature, 508(7494), 52-53. https://doi.org/10.1038/508052a
Marusyk, A., Tabassum, D. P., Altrock, P. M., Almendro, V., Michor, F., & Polyak, K. (2014). Non-cell-autonomous driving of tumour growth supports sub-clonal heterogeneity. Nature, 514(7520), 54-58. https://doi.org/10.1038/nature13556
Marusyk, A., & Polyak, K. (2013). Cancer. Cancer cell phenotypes, in fifty shades of grey. Science, 339(6119), 528-529. https://doi.org/10.1126/science.1234415
Henry, C. J., Marusyk, A., Zaberezhnyy, V., Adane, B., & DeGregori, J. (2010). Declining lymphoid progenitor fitness promotes aging-associated leukemogenesis. Proc Natl Acad Sci U S A, 107(50), 21713-21718. https://doi.org/10.1073/pnas.1005486107
Marusyk, A., & Polyak, K. (2010). Tumor heterogeneity: causes and consequences. Biochim Biophys Acta, 1805(1), 105-117. https://doi.org/10.1016/j.bbcan.2009.11.002
Marusyk, A., & DeGregori, J. (2008). Declining cellular fitness with age promotes cancer initiation by selecting for adaptive oncogenic mutations. Biochim Biophys Acta, 1785(1), 1-11. https://doi.org/10.1016/j.bbcan.2007.09.001
Marusyk, A., Porter, C. C., Zaberezhnyy, V., & DeGregori, J. (2010). Irradiation selects for p53-deficient hematopoietic progenitors. PLoS Biol, 8(3), e1000324. https://doi.org/10.1371/journal.pbio.1000324
Marusyk, A., Wheeler, L. J., Mathews, C. K., & DeGregori, J. (2007). p53 mediates senescence-like arrest induced by chronic replicational stress. Mol Cell Biol, 27(15), 5336-5351. https://doi.org/10.1128/mcb.01316-06