The mission of our research group is to reduce morbidity and mortality from ovarian and breast cancers by enhancing risk prediction models and improving primary and secondary prevention recommendations using an integrative, multidisciplinary approach.
Specifically, we are conducting research to:
- Elucidate how the host macroenvironment both drives tumor development and heterogeneity and interacts with the tumor microenvironment to impact progression of ovarian and breast cancers
- Identify and evaluate novel factors associated with ovarian cancer risk and survival, incorporating information about markers tumor heterogeneity
- Develop and lead consortial research approaches, including being PI of the Ovarian Cancer Cohort Consortium
- Identify how the biologic consequences of psychosocial stress and distress influence carcinogenesis
- Elucidate the hormonal etiology of breast cancer and integrating biologic markers into risk prediction models, with an ultimate goal of identifying approaches to integrate risk prediction into the clinic.