Alice Chan, PhD

Postdoctoral Fellow
Drug Discovery Department



PhD in Biochemistry, Chemistry & Life Sciences - Grenoble University, Grenoble, France


  • Chan A, Karim RM, Zhu J, Schönbrunn E; Structural basis of inhibitor selectivity in the BRD7/9 subfamily of bromodomains. J Med Chem. 2020, 63, 6, 3227-3237. doi: 10.1021/acs.jmedchem.9b01980

  • Paulson CN; Guan X; Ayoub AM; Chan A; Karim RM; Pomerantz WCK; Schönbrunn E; Georg GI; Hawkinson JE; Design, Synthesis, and Characterization of a Fluorescence Polarization Pan-BET Bromodomain Probe. ACS Med Chem Lett. 2018 Oct 31;9(12):1223-1229

  • Cherrier, M. V.; Chan, A.; Darnault, C.; Reichmann, D.; Amara, P.; Ollagnier de Choudens, S.; Fontecilla-Camps, J. C., The crystal structure of Fe₄S₄ Quinolinate Synthase unravels an enzymatic dehydration mechanism that uses tyrosine and a hydrolase-type triad. J Am Chem Soc 2014, 136 (14), 5253-6.

  • Chan, A.; Clémancey, M.; Mouesca, J. M.; Amara, P.; Hamelin, O.; Latour, J. M.; Ollagnier de Choudens, S., Studies of inhibitor binding to the [4Fe-4S] cluster of Quinolinate Synthase. Angew Chem Int Ed Engl 2012, 51 (31), 7711-4.