Education
PhD in Biochemistry - University of Alberta, Canada, 2018
Publications
- Faber EB, Wang N, John K, Sun L, Wong HL, Burban D, Francis R, Tian D, Hong KH, Yang A, Wang L, Elsaid M, Khalid H, Levinson NM, Schönbrunn E, Hawkinson JE, Georg GI. Screening through Lead Optimization of High Affinity, Allosteric Cyclin-Dependent Kinase 2 (CDK2) Inhibitors as Male Contraceptives That Reduce Sperm Counts in Mice. J Med Chem. 2023 Feb 9;66(3):1928-1940. doi: 10.1021/acs.jmedchem.2c01731. Epub 2023 Jan 26. PMID: 36701569.
- Liao Y, Chin Chan S, Welsh EA, Fang B, Sun L, Schönbrunn E, Koomen JM, Duckett DR, Haura EB, Monastyrskyi A, Rix U. Chemical Proteomics with Novel Fully Functionalized Fragments and Stringent Target Prioritization Identifies the Glutathione-Dependent Isomerase GSTZ1 as a Lung Cancer Target. ACS Chem Biol. 2023 Feb 17;18(2):251-264. doi: 10.1021/acschembio.2c00587. Epub 2023 Jan 11. PMID: 36630201.
- Xiao T, Sun L, Zhang M, Li Z, Haura EB, Schönbrunn E, Ji H (2021). Synthesis and structural characterization of a monocarboxylic inhibitor for GRB2 SH2 domain. Bioorg Med Chem Lett 51:128354 PMID 34506932
- Hanna CB, Mudaliar D, John K, Allen CL, Sun L, Hawkinson JE, Schönbrunn E, Georg GI, Jensen JT (2020). Development of WEE2 kinase inhibitors as novel non-hormonal female contraceptives that target meiosis. Biol Reprod. 103:368-377 PMID 32667031
- Sun, L., Huang, Y., Edward, R. Glover, J.N.M. Structural insight into BLM recognition by TopBP1. Structure 25，1582-1588. (2017)
- Ayoub, A., Ahmed, R., Tilli, T., Arakawa, K., Sun, L., Glover, J.N.M., Klobukowski, M., Tuszynski, J. Antitumor activity of lankacidin antibiotics is due to microtubule stabilization via a taxol-like mechanism. Journal of Medicinal Chemistry. 59(20): 9532-9540. (2016)
- White, E., Sun, L., Ma Z., Beckta, J., Danzig, B., Hacker, D., Huie, Melissa., William, D., Edwards, R., Valerie, K., Glover, J.N.M., Hartman, M. A peptide library approach to uncover phosphomimetic inhibitors of BRCA1 C-terminal domain. ACS Chemical Biology, 10(5): 1198-208. (2015)
- Leung, C., Sun, L., Gong, Z., Burkat, M., Edwards, R., Assmus, M., Chen, J., Glover, J.N.M. Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control. Structure. 21,1450-1459. (2013)
- Song, X., Lopez-Campistrous, A., Sun, L., Dower, N.A., Kedei, N., Yang, J., Kelsey, J.S., Lewin, N.E., Esch, T.E., Blumberg, P.M., Stone, J.C. RasGRPs are targets of the anti-cancer agent ingenol-3-angelate. PLoS One.8(8), e72331. (2013)
E. Schönbrunn Laboratory
