2021 - 2018


Burger K, Meads M, Sudalagunta P, Fernandez M, Oliveira P, Canevarolo R, Alugubelli R,Tungsevik A, Avila G, Silva M, Distler A, Dai H, Kulkarni A, Hampton O, Koomen J, Roush W, Monastyrskyi A,Berglund A,Silva A, Cleveland J, Shain K. CK1δ/CK1ε Signaling is Necessary to Sustain mitochondrial Metabolism and Cell Survival in Multiple Myeloma. Submitted to Cancer Discovery.

Canevarolo R, Meads M, Silva M, Sudalagunta P, Avila G, Alugubelli R, Tungesvik A, Bell E, Burger K, Kulkarni A, Hampton O, Jiang Z, Dai H, Cubitt C, Teer J, Welsh E, Yoder S, Shah B, Tao J, Hazlehurst L, Gatenby R, Sullivan D, Alsina M, Nishihori T, Brayer J, Cleveland J, Dalton W, Gillies R, Baz R, Shain K, Silva A. Dynamic super-enhancer core regulatory circuits and epigenetic landscapes drive malignant progression and refractory disease in multiple myeloma. Pre-print version.

Hasipek M, Grabowski D,Guan Y, Alugubelli R,Tiwari A, Gu X, deAvila G, Silva A, Meads M, Parker Y, Lindner D, Saunthararajah Y, Shain K, Maciejewski J, Reu F, Phillips J, Jha B. Therapeutic Targeting of Protein Disulfide Isomerase PDIA1 in Multiple Myeloma. Under review at Cancers.

Koomen D, Meads M, Magaletti D, Guingab-Cagmat J, Oliveira P, Fang B, Liu M, Welsh E, Meke L, Jiang Z, Hampton O, Tungesvik A, De Avila G, Alugubelli R, Nishihori T, Silva A, Eschrich S, Garrett T, Koomen J, Shain K. Metabolic Changes are Associated with Melphalan Resistance in Multiple Myeloma. Under Review at  Journal of Proteome Research.

Mostofa AGM, Distler A, Meads MB, Sahakian E, Powers JJ, Achille A, Noyes D, Wright G, Ramakrishnan R, Nguyen T, Avilla G, Silva A, Sudalagunta P, Renatino-Canevarolo R, Silva MD, Alugubelli R, Dai H, Kulkarni A, Dalton WS, Hampton O, Welsh E, Teer J, Tungesvik A, Pinilla-Ibarz J, Sotomayor EM, Shain KH and Brayer J. Key Functional Analysis of HDAC11 In Plasma Cell Development and Multiple Myeloma Survival. Manuscript under review at Blood. 

Zhao X, Wang MY, Jiang H, Lwin T, Park PM, Gao J, Meads MB, Ren Y, Li T, Sun J, Fahmi NA, Singh S, Sehgal L, Wang X, Silva AS, Sotomayor EM, Shain KH, Cleveland JL, Wang M, Zhang W, Qi J, Shah BD, Tao J. Transcriptional programming drives Ibrutinib-resistance evolution in mantle cell lymphoma. Cell Rep. 2021;34(11):108870. PMID: 33730585

Tichacek CJ, Tafreshi NK, Kil H, Engelman RW, Doligalski ML, Budzevich MM, Gage KL, McLaughlin ML, Wadas TJ, Silva A, Moros E, Morse DL. Biodistribution and Multicompartment Pharmacokinetic Analysis of a Targeted alpha Particle Therapy. Mol Pharm. 2020;17(11):4180-8. PMID: 32960613

Enderling H, Altrock PM, Andor N, Basanta D, Brown JS, Gatenby RA, Marusyk A, Rejniak KA, Silva A, Anderson ARA. High School Internship Program in Integrated Mathematical Oncology (HIP IMO): Five-Year Experience at Moffitt Cancer Center. B Math Biol. 2020;82(7). PMID: 32648152

Sudalagunta PR, Silva M, Canevarolo R, Meads M, Shain KH, Silva AS. A pharmacodynamic model of clinical synergy in multiple myeloma. EBioMedicine. 2020 Apr;54:102716. PMID: 32268267

Zhao X, Ren Y, Lawlor M, Shah BD, Park PMC, Lwin T, Wang X, Liu K, Wang M, Gao J, Li T, Xu M, Silva AS, Lee K, Zhang T, Koomen JM, Jiang H, Sudalagunta PR, Meads MB, Cheng F, Bi C, Fu K, Fan H, Dalton WS, Moscinski LC, Shain KH, Sotomayor EM, Wang GG, Gray NS, Cleveland JL, Qi J, Tao J. BCL2 Amplicon Loss and Transcriptional Remodeling Drives ABT-199 Resistance in B Cell Lymphoma Models. Cancer Cell. 2019;35(5):752-66.e9. PMID: 31085176

Ren Y, Bi C, Zhao X, Lwin T, Wang C, Yuan J, Silva AS, Shah BD, Fang B, Li T, Koomen JM, Jiang H, Chavez JC, Pham LV, Sudalagunta PR, Wan L, Wang X, Dalton WS, Moscinski LC, Shain KH, Vose J, Cleveland JL, Sotomayor EM, Fu K, Tao J. PLK1 stabilizes a MYC-dependent kinase network in aggressive B cell lymphomas. J Clin Invest. 2018;128(12):5517-30. PMID: 30260324

Shah B, Zhao X, Silva AS, Shain KH, Tao J. Resistance to Ibrutinib in B Cell Malignancies: One Size Does Not Fit All. Trends Cancer. 2018 Mar;4(3):197-206. PMID: 29506670


2017 - 2014


Maley CC, Aktipis A, Graham TA, Sottoriva A, Boddy AM, Janiszewska M, Silva A, Gerlinger M, Yuan Y, Pienta KJ, Anderson KS, Gatenby R, Swanton C, Posada D, Wu C, Polyak K, Anderson A, Brown JS, Greaves M, Shibata D. Classifying the evolutionary and ecological features of neoplasms. Nat Rev Cancer. 2017 Oct;17(10):605-619. PMID: 28912577

Emmons MF, Anreddy N, Cuevas J, Prater K, McLaughlin M, Silva A, and Hazlehurst LA. MTI-101 treatment inducing activation of Stim1 and TRPC1 expression is a determinant of response in multiple myeloma. Sci Rep. 2017 Jun 2;7(1):2685. PMID: 28578393

Silva AS, Silva MC, Sudalagunta P, Distler A, Jacobson T, Collins A, Song J, Chen D, Chen L, Cubitt C, Baz R, Perez L, Rebatchouk D, Dalton W, Greene J, Gatenby R, Gillies R, Sontag E, Meads MB, Shain KH. An ex vivo platform for the prediction of clinical response in multiple myeloma. Cancer Res. 2017 Jun 15;77(12):3336-3351. PMID: 28400475

Xiaohong Z, Lwin T, Silva A, Shah B, Tao J, Fang B, Zhang L, Li J, Meads M, Jacobson T, Silva M, Distler A, Zhang L, Han Y, Moscinski L, Koomen J, Dalton W, Shain K, Wang M, Sotomayor E, Tao J. Unification of environment-mediated and Acquired Ibrutinib Resistance in B Cell Malignancies. Nat Commun. 2017 Apr 18;8:14920. PMID: 28416797

Enriquez-Navas PM, Kam Y, Das T, Hassan S, Silva A, Foroutan P, Ruiz E, Martinez G, Minton S, Gillies RJ, Gatenby RA. Exploiting evolutionary principles to prolong tumor control in preclinical models of breast cancer. Sci Transl Med. 2016 Feb 24;8(327):327ra24. PMID: 26912903

Silva A, Durand S, Ribeiro M, Alsina M, Shain K, Baz R. An Evolutionary Approach for Personalized Therapy in Multiple Myeloma. Applied Mathematics, 2016, 7, 159-169. SciRP.org

Silva A, Jacobson T, Meads M, Distler A, Shain K. An Organotypic High Throughput System for Characterization of Drug Sensitivity of Primary Multiple Myeloma Cells. J Vis Exp. 2015 Jul 15;(101):e53070. PMID: 26274375

Khin ZP, Ribeiro MC, Jacobson T, Hazlehurst LA, Perez L, Baz R, Shain KH, Silva AS. A preclinical assay for chemosensitivity in multiple myeloma. Cancer Res. 2014 Jan 1;74(1):56-67. PMID: 24310398

2013 - 2010


Tafreshi NK, Silva A, Estrella VC, McCardle TW, Chen T, Jeune-Smith Y, Lloyd MC, Enkemann SA, Smalley KSM, Sondak VK, Vagner J, Morse DL. In Vivo and in Silico Pharmacokinetics and Biodistribution of a Melanocortin Receptor 1 Targeted Agent in Preclinical Models of Melanoma. Mol Pharm. 2013 Aug 5;10(8):3175-85. PMID: 23763620

Ribeiro MdLC, Silva AS, Bailey KM, Kumar NB, Sellers TA, et al. Buffer Therapy for Cancer. J Nutr Food Sci. 2012 Aug 15;2:6. PMID: 24371544

Silva AS, Kam Y, Khin Z, Minton S, Gillies RJ, Gatenby RA. Evolutionary approaches to prolong progression-free survival in breast cancer. Cancer Res. 2012 Dec 15;72(24):6362-70. PMID: 23066036

Silva AS, Gatenby RA. Adaptation to Survival in Germinal Center Is the Initial Step in Onset of Indolent Stage of Multiple Myeloma. Mol Pharm. 2011 Dec 5;8(6):2012-20. PMID: 21958215

Lee HO, Silva AS, Concilio S, Li YS, Slifker M, Gatenby RA, Cheng JD. Evolution of tumor invasiveness: the adaptive tumor microenvironment landscape model. Cancer Res. 2011 Oct 15;71(20):6327-37. PMID: 21859828

Silva AS, Anderson AR, Gatenby RA. A multiscale model of the bone marrow and hematopoiesis. Math Biosci Eng. 2011 Apr;8(2):643-58. PMID: 21631151

Assumpcao JG, Ganazza MA, de Araujo M, Silva AS, Scrideli CA, Brandalise SR, Yunes JA. Detection of clonal immunoglobulin and T-cell receptor gene rearrangements in childhood acute lymphoblastic leukemia using a low-cost PCR strategy. Pediatr Blood Cancer. 2010 Dec 15;55(7):1278-86. PMID: 20730889

Silva AS, Gatenby RA. A theoretical quantitative model for evolution of cancer chemotherapy resistance. Biol Direct. 2010 Apr 20;5:25. PMID: 20406443

Silva AS, Gatenby RA, Gillies RJ, Yunes JA. A Quantitative Theoretical Model for Development of Malignancy in Ductal Carcinoma In Situ. J Theor Biol. 2010 Feb 21;262(4):601-13. PMID: 19887072


2009 - 2006


Gatenby RA, Silva AS, Gillies RJ, Frieden BR. Adaptive Therapy. Cancer Res. 2009 Jun 1;69(11):4894-903. PMID: 19487300

Silva AS, Yunes JA, Gillies RJ, Gatenby RA. The potential role of systemic buffers in reducing intratumoral pHe and acid-mediated invasion. Cancer Res. 2009 Mar 15;69(6):2677-84. PMID: 19276380

Silva AS, Yunes JA. Conservation of glycolytic oscillations in Saccharomyces cerevisiae and human pancreatic beta-cells: a study of metabolic robustness. Genet Mol Res. 2006 Aug 31;5(3):525-35. PMID: 17117368