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Lab Research Overview

The Smalley lab is at the forefront of melanoma research, focusing on the immune environment, biology and therapeutic management of the deadliest form of skin cancer.  Our research focus includes various melanoma subtypes; cutaneous, acral, pediatric, and uveal melanomas, as well as melanoma brain metastases. We utilize cutting-edge techniques such as Single Cell RNA-Seq, PROTACS, spatial transcriptomics, advanced proteomics and other omics platforms to investigate signaling adaptations, immune evasion, host-tumor interactions, and epigenetic modifications. The overarching goal of our group is to develop novel immunotherapies (checkpoint inhibitors, and T cell therapies) and targeted therapies (including epigenetic modulators and RAS inhibitor) that can be translated into the clinic.