The Smalley lab studies the biology and therapeutic management of melanoma, the deadliest of all skin cancers. We use cutting edge techniques such as phospho-proteomics, Single Cell RNA-Seq, ATAC-Seq, Chip-Seq and other omics platforms to understand signaling adaptation, host-tumor crosstalk and epigenetic remodeling. Our focus includes cutaneous melanoma, acral melanoma, pediatric melanoma, melanoma brain metastases and uveal melanoma. The work is highly translational in nature and has led to multiple clinical trials.