I joined in Dr. Schonbrunn's lab in November 2008 and I participate in several of his drug discovery projects. My main poject is the developement of inhibitors of the Cyclin Dependant protein Kinase (CDK2).
My research focuses on molecular modelling derived form the lab structural biology and SAR (Structural Activity Relatioship) programs.
I also take part in the structural biology projects where I perform the refinement of protein structures and some biochemistry and molecular biololgy experiments.
2008 PHD in Structural Biology, Bioinformatics and Genomic (Marseille Provence University U1 - France). TItle: "Protein Protein Interaction Inhibition: Application to antiviral design".
2004 DEA (one year before PhD) : Structural Biology, Bioinformatics and Genomic - option Structural Biology (Marseille Provence University U1 - France)
2003 Master degree : Biochemistry option structural Biology (Marseille Provence University U1 - France)
Molecular modelling: Pymol, Sybyl (Tripos), Lithium (Tripos), MOE (Chemical Computing Group Inc.), Maestro (Shrodinger)
Structure-Based drug design: Docking and High Throughput docking (FlexX, Glide, Surflex, CScore, GFscore)
Ligand-Based drug design: QSAR, CoMFA
Structural Biology and Biochemistry : Refinement of Xray protein structures (CNS). Proteins sample preparation for Xray and NMR. Protein purifications. Microcalorimetry (ITC).
Operating systems: Windows, Linux.
Webdesign: HTML, CSS, Dreamweaver, Photoshop
2008 to 2010 Postdoctorate Position, Dr E. Schonbrunn Laboratory Moffitt Cancer Research
2007 to 2008 ATER (Assistant teacher) Marseille Provence University U1 ("Université de Provence") in biochemistry . Research at NMR group, IMR laboratory CNRS France
2005 to 2007
Research: PhD in Structural Biology, Bioinformatics and Genomic (Marseille Provence University U1 - France). Title: "Protein Protein Interaction Inhibition: Application to antiviral design".
Directors: Xavier MORELLI and Françoise GUERLESQUIN (IMR laboratory, CNRS France)
Teaching: Lecturer at Marseille Provence University U1 ("Université de Provence"): Biochemistry 100 hours a year, Docking and virtual screening 16 hours a year
Webdesign and Webmaster: Schonbrunn Laboratory: http://labpages.moffitt.org/schonbrunne/
2004 6 months training period : NMR group, BIP laboratory CNRS France (Structure-Based Drug Design of Nef/SH3 protein/protein interaction using NMR for validation)
2003 1 month training period : NMR group, BIP laboratory CNRS France
FlexX Docking Workshop 10 to 11 November 2006 Bonn Germany
Designing Active Ligands with QSAR/CoMFA 16 November 2005 Tripos Paris
October 2007 FJC (Forum Jeunes Chercheurs) Les Embiez France - Oral presentation
March 2005 Structure-Based Drug Design - Cambridge Healthtech Institute 2005 Boston US
April 2005 GERM (Groupement français d'Etudes de Résonance Magnétique) Carry-le-Rouet France
May 2005 GGMM (Groupe de Graphisme et Modélisation Moléculaire) Les Embiez France