Publications

PUBLICATIONS

Newberg JY, Black MA Jenkins NA, Copeland NG, Mann KM, Mann MB. SB Driver Analysis: a Sleeping Beauty cancer driver analysis framework for identifying and prioritizing experimentally actionable oncogenes and tumor suppressors. Nucleic Acids Res, 2018 May 26; 

Newberg JY, Mann KM, Mann MB, Jenkins NA and Copeland NG. SBCDDB: Sleeping Beauty Cancer Driver Database for gene discovery in mouse models of human cancers. Nucleic Acids Res, 2018 Jan; 46(D1): D1011-D1017

Mann KM, Newberg JY, Black MA, Jones DJ, Amaya-Manzanares F, Guzman-Rojas L, Kodama T, Ward J, Rust AG, van der Weyden L, Chin KY, Waters J, Leung ML, Rogers K, Rogers SM, McNoe L, Selvanesan L, Navin N, Jenkins NA, Copeland NG, and Mann MB. Analyzing tumor heterogeneity and driver genes in single myeloid leukemia cells with SBCapSeq. Nature Biotechnology, 2016 Sep; 34(9):962-72.

Mann KM, Ying H, Juan J, Jenkins NA, Copeland NG. KRAS-related proteins in pancreatic cancer. Pharmacol Ther. 2016 Sep 3. pii: S0163-7258(16)30159-0.

Goh AM, Xue Y, Leushacke M, Li L, Wong JS, Chiam PC, Rahmat SA, Mann MB, Mann KM, Barker N, Lozano G, Terzian T, Lane DP. Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice. Oncotarget. 2015 Jul 20;6(20):17968-80

Mann MB, Jenkins NA, Copeland NG and Mann KM. Sleeping Beauty mutagenesis: exploiting forward genetic screens for cancer gene discovery. Current Opinion in Genetics and Development. 2014 Feb;24:16-22

Mann KM, Jenkins NA, Copeland NG and Mann MB. Transposon Insertional Mutagenesis Models of Cancer. Cold Spring Harb Protoc. 2014 Mar 1;2014(3)

Mann KM, Ward JM, Yew CC, Kovochich A, Dawson DW, Black MA, Brett BT, Sheetz TE, Dupuy AJ; Australian Pancreatic Cancer Genome Initiative, Chang DK, Biankin AV, Waddell N, Kassahn KS, Grimmond SM, Rust AG, Adams DJ, Jenkins NA, Copeland NG. Sleeping Beauty Mutagenesis Reveals Cooperating Mutations and Pathways in Pancreatic Adenocarcinoma. Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):5934-41

 Biankin, AV et al.** Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes. Nature. 2012 Nov 15;491(7424):399-405

** This is a paper from the International Cancer Genome Consortium (ICGC) for pancreatic cancer to which I contributed data from our Sleeping Beauty model of pancreatic cancer as independent validation of mutated genes identified by whole exome sequencing of human cancer patients.

 Goh AM, Lim CY, Chiam PC, Li L, Mann MB, Mann KM, Menendez S, Lane DP. Using targeted transgenic reporter mice to study promoter-specific p53 transcriptional activity. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1685-90. Epub 2012 Jan 17.

 Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, Tontonoz P, Landreth GE. ApoE promotes the proteolytic degradation of Abeta. Neuron, June 2008, Vol. 58 No. 5

 Mann KM, Thorngate FE, Katoh-Fukui Y, Hamanaka H, Williams DL, Fujita S, Lamb BT “Independent effects of APOE on cholesterol metabolism and brain Aβ levels in an Alzheimer disease mouse model.” Human Molecular Genetics. September, 2004, Vol. 13 No. 17

 Lehman EJ, Kulnane LS, Gao Y, Petriello MC, Pimpis* KM, Younkin L, Dolios G, Wang R, Younkin SG, Lamb BT. Genetic background regulates beta-amyloid precursor protein processing and beta-amyloid deposition in the mouse.” Human Molecular Genetics. November, 2003, Vol.12 No. 22

*Maiden name