Sleeping Beauty Insertional Mutagenesis
Sleeping Beauty is a gene discovery tool in mice that models the iterative process of mutation and selection during cancer development.
Pancreatic Cancer Metastasis Drivers
We study novel drivers differentially expressed during tumor progression that confer metastatic potential using mouse models of pancreatic cancer.
Cooperating drivers and tumor evolution
We use single cell sequencing to identify cooperating drivers in tumor sub clones that contribute to disease initiation, progression, and therapeutic response.